Jamin D. Steffen

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

Jennine M. Dawicki-McKenna, Marie-France Langelier, Jamie E. DeNizio et al. · Molecular Cell · 2015 · 353 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +8

Structural basis for allosteric PARP-1 retention on DNA breaks

Levani Zandarashvili, Marie-France Langelier, Uday Kiran Velagapudi et al. · Science · 2020 · 331 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Targeting PARP-1 Allosteric Regulation Offers Therapeutic Potential against Cancer

Jamin D. Steffen, Renee Tholey, Marie-France Langelier et al. · Cancer Research · 2013 · 66 citations · Full text

Medicine, Molecular Biology, Oncology +14

Investigation of the Lactam Side Chain Length Necessary for Optimal Indenoisoquinoline Topoisomerase I Inhibition and Cytotoxicity in Human Cancer Cell Cultures

Andrew Morrell, Michael S. Placzek, Jamin D. Steffen et al. · Journal of Medicinal Chemistry · 2007 · 59 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Detection of urine DNA markers for monitoring recurrent hepatocellular carcinoma

Hie‐Won Hann, Surbhi Jain, Grace Park et al. · Hepatoma Research · 2017 · 58 citations · Full text

Medicine, Oncology, Pathology +17