Cordycepin Modulates Microglial M2 Polarization Coupled with Mitochondrial Metabolic Reprogramming by Targeting HKII and PDK2

Xin Zhong, Shiqiang Gong, Linghui Meng, +10

Advanced Science

Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs

Shuai Li, Xinyang Li, Tingjian Zhang, +4

Bioorganic Chemistry

Medicinal ChemistryDerivative (Chemistry)BiochemistryMedicineNatural Sciences +10

Design, synthesis and anticancer activities evaluation of novel 5H-dibenzo[b,e]azepine-6,11-dione derivatives containing 1,3,4-oxadiazole units

Xin He, Xinyang Li, Jingwei Liang, +4

Bioorganic & Medicinal Chemistry Letters

Network pharmacology-based identifcation of potential targets of the flower of Trollius chinensis Bunge acting on anti-inflammatory effectss

Jingwei Liang, Mingyang Wang, Kamara Mohamed Olounfeh, +3

Scientific Reports

Design, synthesis and biological evaluation of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide derivatives as thymidylate synthase (TS) inhibitors and as potential antitumor drugs

Xinyang Li, Jingwei Liang, Kamara Mohamed Olounfeh, +3

European Journal of Medicinal Chemistry

Medicinal ChemistryDerivative (Chemistry)Bioorganic ChemistryMedicineNatural Sciences +10

Gene Silencing of FANCF Potentiates the Sensitivity to Mitoxantrone through Activation of JNK and p38 Signal Pathways in Breast Cancer Cells

Yanlin Li, Lin Zhao, Haigang Sun, +11

PLoS ONE

P38 Signal PathwaysBreast OncologyCell RegulationMedicineBreast Cancer Cells +12

Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model

Jingwei Liang, Mingyang Wang, Shan Wang, +3

Journal of Enzyme Inhibition and Medicinal Chemistry

Drug TargetHit IdentificationChemoprevention StrategyNovel Cdk2 InhibitorsMedicinal Chemistry +14

Predicting potential antitumor targets of Aconitum alkaloids by molecular docking and protein–ligand interaction fingerprint

Jingwei Liang, Tingjian Zhang, Zuojing Li, +3

Medicinal Chemistry Research

Molecular DockingPotential Antitumor TargetsDrug TargetBiochemistryMedicine +6

A Comprehensive In Silico Method to Study the QSTR of the Aconitine Alkaloids for Designing Novel Drugs

Mingyang Wang, Jingwei Liang, Kamara Mohamed Olounfeh, +3

Molecules

Potential Protein TargetsCellular PharmacologySystem PharmacologyDesigning Novel DrugsMolecular Pharmacology +14

2-((1-Phenyl-1H-1,2,3-triazol-4-yl)methyl)-2-azabicyclo[3.2.1]octan-3-one derivatives: Simplification and modification of aconitine scaffold for the discovery of novel anticancer agents

Yi Zhang, Tingjian Zhang, Xinyang Li, +8

European Journal of Medicinal Chemistry

Combinatorial ChemistryAconitine ScaffoldMedicinal ChemistryDerivative (Chemistry)Novel Anticancer Agents +7