Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

Ken Coppieters, Francesco Dotta, Natalie Amirian, +5

The Journal of Experimental Medicine

Long-term Type 1T-regulatory CellImmunologyImmune RegulationPathology +16

Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes

Teresa Rodríguez-Calvo, Olov Ekwall, Natalie Amirian, +2

Diabetes

Clinical ImmunologyAdaptive Immune SystemImmunologyImmune RegulationPathology +24

Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset

Teresa Rodríguez-Calvo, Jose Zapardiel‐Gonzalo, Natalie Amirian, +5

Diabetes

ImmunologyPathologyCytoskeletonInsulin SignalingInsulin Production +17

Intravital imaging of CTLs killing islet cells in diabetic mice

Ken Coppieters, Natalie Amirian, Matthias von Herrath

Journal of Clinical Investigation

EngineeringImmunologyCellular PhysiologyInsulin SignalingCell Interaction +19

The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes

Christine Bender, Teresa Rodríguez-Calvo, Natalie Amirian, +2

Science Advances

Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase

Teresa Rodríguez-Calvo, Jessica S. Suwandi, Natalie Amirian, +4

Journal of Histochemistry & Cytochemistry

Prediabetic PhaseImmunologyPathologyPancreas TransplantationImmunotherapy +15

A Novel Technique for the In Vivo Imaging of Autoimmune Diabetes Development in the Pancreas by Two-Photon Microscopy

Ken Coppieters, Marianne M. Martinic, William B. Kiosses, +2

PLoS ONE

EngineeringLaboratory ImmunologyMicroscopyImmunologyBiomedical Engineering +18

Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals

Ken Coppieters, Anna Wiberg, Natalie Amirian, +2

Diabetes/Metabolism Research and Reviews

Alpha cells, the main source of IL-1β in human pancreas

Florence Anquetil, Somayeh Sabouri, Charles Thivolet, +7

Journal of Autoimmunity

InflammationCytokineMolecular PhysiologyPancreatic CancerImmune Regulation +8

Functional Redundancy of CXCR3/CXCL10 Signaling in the Recruitment of Diabetogenic Cytotoxic T Lymphocytes to Pancreatic Islets in a Virally Induced Autoimmune Diabetes Model

Ken Coppieters, Natalie Amirian, Philippe P. Pagni, +6

Diabetes

T-regulatory CellImmunologyImmune RegulationImmunologic MechanismActivated Ctls +21