Heteronemin, a spongean sesterterpene, inhibits TNFα-induced NF-κB activation through proteasome inhibition and induces apoptotic cell death

Marc Schumacher, Claudia Cerella, Serge Eifes, +5

Biochemical Pharmacology

InflammationProteasome InhibitionAnti-inflammatorySpongean SesterterpeneMedicine +9

Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1

Karolien De Bosscher, Ilse M. Beck, Lien Dejager, +10

Cellular and Molecular Life Sciences

ImmunologyImmune RegulationBlock InflammationGlucocorticoidGlucocorticoid Receptor +22

Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells

Marion Orsini, Sébastien Chateauvieux, Jiyun Rhim, +6

Cell Death and Differentiation

Tumor necrosis factor α inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK pathway, GATA-1 and FOG-1 downregulation and GATA-2 upregulation

Isabelle Buck, Franck Morceau, Silvia Cristofanon, +5

Biochemical Pharmacology

InflammationCytokineApoptosisImmune RegulationPathology +6

Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450

Claudia Cerella, Fritz Müller, Anthoula Gaigneaux, +5

Cell Death and Disease

Chemoprevention StrategyApoptosisCell DeathPotent Anti-cancer ActivitiesCardiovascular Toxicity +21

Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU.1 over-expression

Christine Grigorakaki, Franck Morceau, Sébastien Chateauvieux, +2

Biochemical Pharmacology

InflammationGata-1/gata-2 Balance ImpairmentCytokineAutoimmune DiseasePu.1 Over-expression +12

Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation

Carmela Spagnuolo, Claudia Cerella, Maria Russo, +3

British Journal of Cancer

Identification of Differentially Expressed Proteins in Curcumin-Treated Prostate Cancer Cell Lines

Marie-Hélène Teiten, Anthoula Gaigneaux, Sébastien Chateauvieux, +8

OMICS A Journal of Integrative Biology

Primary PreventionChemoprevention StrategyOncogenic AgentMedicineProteomics +13

Eurycomanone and Eurycomanol from Eurycoma longifolia Jack as Regulators of Signaling Pathways Involved in Proliferation, Cell Death and Inflammation

Shéhérazade Hajjouli, Sébastien Chateauvieux, Marie‐Hélène Teiten, +5

Molecules

Chemoprevention StrategyApoptosisCell DeathCancer BiologyHealthy Donors +14

Valproic acid perturbs hematopoietic homeostasis by inhibition of erythroid differentiation and activation of the myelo-monocytic pathway

Sébastien Chateauvieux, Serge Eifes, Franck Morceau, +5

Biochemical Pharmacology

InflammationHematological MalignancyMedicineMalignant Blood DisorderHematology +9