Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition

Annelyse Duvoix, Franck Morceau, Sylvie Delhalle, +5

Biochemical Pharmacology

Chemoprevention StrategyMedicineLipid PeroxidationApoptosisCell Death +4

Heteronemin, a spongean sesterterpene, inhibits TNFα-induced NF-κB activation through proteasome inhibition and induces apoptotic cell death

Marc Schumacher, Claudia Cerella, Serge Eifes, +5

Biochemical Pharmacology

InflammationProteasome InhibitionAnti-inflammatorySpongean SesterterpeneMedicine +9

Inhibition of TNFα-induced activation of nuclear factor κB by kava (Piper methysticum) derivatives

Florence Folmer, Romain Blasius, Franck Morceau, +4

Biochemical Pharmacology

InflammationMolecular PharmacologyMedicinal ChemistryAnti-inflammatoryPiper Methysticum +8

UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

Tom Juncker, Claudia Cerella, Marie‐Hélène Teiten, +8

Biochemical Pharmacology

Hematological MalignancyChemoprevention StrategyMedicineMalignant Blood DisorderApoptosis +9

Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibition

Annelyse Duvoix, Sylvie Delhalle, Romain Blasius, +7

Biochemical Pharmacology

Reductive StressSignal TransductionChemopreventive AgentsBiochemistryProtein Expression +5

Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells

Marion Orsini, Sébastien Chateauvieux, Jiyun Rhim, +6

Cell Death and Differentiation

Linking anemia to inflammation and cancer: The crucial role of TNFα

Isabelle Buck, Franck Morceau, Christina Grigorakaki, +2

Biochemical Pharmacology

InflammationCytokineInflammatory DiseaseCrucial RoleImmune Regulation +8

Tumor necrosis factor α inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK pathway, GATA-1 and FOG-1 downregulation and GATA-2 upregulation

Isabelle Buck, Franck Morceau, Silvia Cristofanon, +5

Biochemical Pharmacology

InflammationCytokineApoptosisImmune RegulationPathology +6

Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU.1 over-expression

Christine Grigorakaki, Franck Morceau, Sébastien Chateauvieux, +2

Biochemical Pharmacology

InflammationGata-1/gata-2 Balance ImpairmentCytokineAutoimmune DiseasePu.1 Over-expression +12

Regulation of glutathione S-transferase P1-1 gene expression by NF-kappaB in tumor necrosis factor alpha-treated K562 leukemia cells

Franck Morceau, Annelyse Duvoix, Sylvie Delhalle, +3

Biochemical Pharmacology

InflammationCytokineReductive StressCell RegulationReceptor Tyrosine Kinase +6