Edward J. Cragoe

Pyrazine Diuretics. II. N-Amidino-3-amino-5-substituted 6-Halopyrazinecarboxamides

Edward J. Cragoe, Otto W. Woltersdorf, John B. Bicking et al. · Journal of Medicinal Chemistry · 1967 · 329 citations

Medicine, Medicinal Chemistry, Pharmacology +6

Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts. Structure-activity relationships in the amiloride series.

Gilles L’Allemain, A Franchi, Edward J. Cragoe et al. · Journal of Biological Chemistry · 1984 · 304 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium.

Debra A. Horstman, Suzanne Brandon, Amy L. Wilson et al. · Journal of Biological Chemistry · 1990 · 273 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Angiotensin II-stimulated Na+/H+ exchange in cultured vascular smooth muscle cells. Evidence for protein kinase C-dependent and -independent pathways.

Bradford C. Berk, Michael S. Aronow, T A Brock et al. · Journal of Biological Chemistry · 1987 · 226 citations · Full text

Life Sciences, Pharmacology, Physiology +17

Amiloride inhibits phorbol ester-stimulated Na+/H+ exchange and protein kinase C. An amiloride analog selectively inhibits Na+/H+ exchange.

Jeffrey M. Besterman, W. Stratford May, Harry LeVine et al. · Journal of Biological Chemistry · 1985 · 203 citations · Full text

Life Sciences, Pharmacology, Cell Signaling +7