Norman E. Hughes

Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors

Matthew A. Schiffler, Stephen Antonysamy, Shobha Bhattachar et al. · Journal of Medicinal Chemistry · 2015 · 54 citations · Full text

Pharmacotherapy, Chemical Biology, Experimental Pharmacology +19

Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine Fibroids

Timothy I. Richardson, Christian A. Clarke, Kuo‐Long Yu et al. · ACS Medicinal Chemistry Letters · 2010 · 50 citations · Full text

Medicinal Chemistry, Hormonal Contraceptive, Uterine Fibroids +15

Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design

Spencer B. Jones, Lance A. Pfeifer, Thomas J. Bleisch et al. · ACS Medicinal Chemistry Letters · 2016 · 46 citations · Full text

Excellent Potency, Pharmaceutical Science, Drug Target +20

Synthesis of Conformationally Constrained Arginine and Ornithine Analogues Based on the 3-Substituted Pyrrolidine Framework

Ahmed Mamai, Norman E. Hughes, Alexander Wurthmann et al. · The Journal of Organic Chemistry · 2001 · 28 citations

Diversity Oriented Synthesis, Engineering, Conformationally Constrained Arginine +10

Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1

Katherine M. Partridge, Stephen Antonysamy, Shobha Bhattachar et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 27 citations · Full text

Medicinal Chemistry, Chemoprevention Strategy, Biochemistry +8