Ícaro A. Simon

Structural insights into the lipid and ligand regulation of serotonin receptors

Peiyu Xu, Sijie Huang, Huibing Zhang et al. · Nature · 2021 · 264 citations

Signal Transduction, Biochemistry, G Protein-coupled Receptor +9

GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors

Sijie Huang, Peiyu Xu, Dandan Shen et al. · Molecular Cell · 2022 · 145 citations · Full text

Signal Transduction, G Protein-coupled Receptor, Medicine +10

Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT_2AReceptor Agonists

Christian B. M. Poulie, Eline Pottie, Ícaro A. Simon et al. · Journal of Medicinal Chemistry · 2022 · 29 citations · Full text

Structure–Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT_2A Receptor Agonists

Eline Pottie, Christian B. M. Poulie, Ícaro A. Simon et al. · ACS Chemical Neuroscience · 2023 · 21 citations · Full text

Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3

Aurélien Zarca, Ilze Adlere, Cristina Perpiñá-Viciano et al. · Molecular Pharmacology · 2024 · 12 citations · Full text