MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

Huadong Pei, Lindsey Zhang, Kuntian Luo, +6

Nature

Histone ModificationsChromatinGenome InstabilityTranscriptional RegulationDna Damage Sites +13

Radiation pharmacogenomics: A genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines

Nifang Niu, Yuxin Qin, Brooke L. Fridley, +7

Genome Research

Gambogic acid inhibits the catalytic activity of human topoisomerase IIα by binding to its ATPase domain

Yuxin Qin, Linghua Meng, Chaoxin Hu, +5

Molecular Cancer Therapeutics

LncBook 2.0: integrating human long non-coding RNAs with multi-omics annotations

Li Zhao, Lin Liu, Changrui Feng, +4

Nucleic Acids Research

GeneticsMolecular BiologyTranscriptomics TechnologyMulti-omics AnnotationsGenomics +18

R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II

Hong Zhu, Min Huang, Fan Yang, +10

Molecular Cancer Therapeutics

Activating <i>JAK1</i> mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma

Shuqun Yang, Chonglin Luo, Qingyang Gu, +13

Oncotarget

Caspase-8 preferentially senses the apoptosis-inducing action of NG-18, A gambogic acid derivative, in human leukemia HL-60 cells

Zhijian Tao, Yunlong Zhou, Jin‐Jian Lu, +5

Cancer Biology & Therapy

GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms

Hua Xie, Yuxin Qin, Yunlong Zhou, +5

Acta Pharmacologica Sinica

GliomaMedicineApoptosisCell DeathPharmacological Agent +8

Establishment of a human primary pancreatic cancer mouse model to examine and investigate gemcitabine resistance

Chenlei Wen, Yuxin Qin, Xiaomei Tang, +3

Oncology Reports

Primary CellsOncologyPancreatic CancerTumor HeterogeneityMedicine +13

Discovery and preclinical evaluations of WX-0593, a novel ALK inhibitor targeting crizotinib-resistant mutations

Xile Liu, Lu Zhang, Haiwen Wan, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePreclinical EvaluationsNovel Alk InhibitorCrizotinib-resistant Mutations +5