Concepedia

Manuel L. Merz

ML

5

Publications

181

Citations

5

H-Index

2022

Active since

Affiliations

École Polytechnique Fédérale de Lausanne(Current)

Ca' Foscari University of Venice

University of Padua

Manuel L. Merz is an author at École Polytechnique Fédérale de Lausanne specializing in medicinal chemistry, drug discovery, and protein engineering.

Top concepts

MedicineBiochemistryDrug DiscoveryChemical BiologyNatural SciencesMedicinal ChemistryProtein EngineeringBiomolecular EngineeringPharmacologyPeptide Science

Publications per year

2022–2024

5

Publications

5

De novo development of small cyclic peptides that are orally bioavailable

Manuel L. Merz, Sevan Habeshian, Bo Li et al. · Nature Chemical Biology · 2023 · 99 citations · Full text

Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale

Sevan Habeshian, Manuel L. Merz, Gontran Sangouard et al. · Nature Communications · 2022 · 39 citations · Full text

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation

Alexander L. Nielsen, Zsolt Bognár, Mothukuri Ganesh Kumar et al. · Angewandte Chemie International Edition · 2024 · 18 citations · Full text

Membrane Structure, Combinatorial Chemistry, Large Libraries +20

Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase

Sevan Habeshian, Ganesh A. Sable, Mischa Schüttel et al. · ACS Chemical Biology · 2022 · 13 citations · Full text

Solid Phase, Cyclative Release Strategy, Peptide Engineering +21

Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides

Zsolt Bognár, Mothukuri Ganesh Kumar, Alexander L. Nielsen et al. · Organic & Biomolecular Chemistry · 2022 · 12 citations · Full text

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