Matthew Bruns

Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation.

Angela Nguyen, John C. Kath, Douglas C. Hanson et al. · Molecular Pharmacology · 1996 · 101 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells

Bethany N. Hannafon, Amy Gin, Yi-Fan Xu et al. · Cell Communication and Signaling · 2019 · 67 citations · Full text

Medicine, Cell Biology, Oncology +17

UK‐78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage‐gated potassium channel and inhibits human T cell activation

Douglas C. Hanson, Angela Nguyen, Robert J. Mather et al. · British Journal of Pharmacology · 1999 · 65 citations · Full text

Natural Sciences, Medicinal Chemistry, Pharmacology +17

The SAR of UK-78,282: A novel blocker of human T cell Kv1.3 potassium channels

Laurence E. Burgess, Kevin M. Koch, Kelvin Cooper et al. · Bioorganic & Medicinal Chemistry Letters · 1997 · 20 citations

Natural Sciences, Biophysics, Cell Biology +11

CP-675,206 anti-CTLA4 antibody clinical candidate enhances IL-2 production in cancer patient T cells in vitro regardless of tumor type or stage of disease

Paul C. Canniff, Carol Donovan, Jeffrey J. Burkwit et al. · 2004 · 16 citations

Life Sciences, Immunology, Oncology +17