John C. Kath

Discovery of (10 <i>R</i> )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- <i>2H</i> -8,4-(metheno)pyrazolo[4,3- <i>h</i> ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations

Ted W. Johnson, Paul Richardson, Simon Bailey et al. · Journal of Medicinal Chemistry · 2014 · 571 citations · Full text

Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor

Jill K. Slack‐Davis, Karen H. Martin, Robert W. Tilghman et al. · Journal of Biological Chemistry · 2007 · 475 citations · Full text

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

W. Gregory Roberts, Ethan Ung, Pamela Whalen et al. · Cancer Research · 2008 · 379 citations · Full text

Antitumor Activity, Cell Adhesion, Focal Adhesion Plaques +18

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

Qian Zhao, Xiaohu Ouyang, Xiaobo Wan et al. · Journal of the American Chemical Society · 2017 · 358 citations

Drug Target, Biomolecular Tool, Molecular Biology +21

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

Bryan Lanning, Landon R. Whitby, Melissa M. Dix et al. · Nature Chemical Biology · 2014 · 356 citations · Full text

Molecular Docking, Drug Target, Biochemistry +10