Xiao-Yao Leng

Cataract-causing mutation S228P promotes βB1-crystallin aggregation and degradation by separating two interacting loops in C-terminal domain

Liangbo Qi, Lidan Hu, Huihui Liu et al. · Protein & Cell · 2016 · 39 citations · Full text

Protein Assembly, S228p Mutation, Molecular Biology +16

The importance of the last strand at the C-terminus in βB2-crystallin stability and assembly

Kai Zhang, Weijie Zhao, Xiao-Yao Leng et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2013 · 31 citations

Crystal Structure, Biochemistry, Protein Assembly +8

The Benefits of Being β-Crystallin Heteromers: βB1-Crystallin Protects βA3-Crystallin against Aggregation during Co-refolding

Sha Wang, Xiao-Yao Leng, Yong‐Bin Yan · Biochemistry · 2011 · 29 citations

Engineering, Protein Assembly, Molecular Biology +21

Congenital microcornea-cataract syndrome-causing mutation X253R increases βB1-crystallin hydrophobicity to promote aggregate formation

Xiao-Yao Leng, Haiyun Li, Jing Wang et al. · Biochemical Journal · 2016 · 23 citations

X-ray Crystallography, Lifelong Stability, Ocular Disease +17

The N-Terminal Extension of βB1-Crystallin Chaperones β-Crystallin Folding and Cooperates with αA-Crystallin

Xiao-Yao Leng, Sha Wang, Ni-Qian Cao et al. · Biochemistry · 2014 · 21 citations

Protein Chemistry, Crystal Structure, Protein Function +15