Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial

Richard Russell, Latifa Chachi, J. Mark FitzGerald, +21

The Lancet Respiratory Medicine

InflammationAsthmaPlacebo-controlled Phase 2Eosinophilic Airway InflammationAllergy +8

DP ₂ antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment

Ruth Saunders, Himanshu Kaul, Rachid Berair, +14

Science Translational Medicine

<i>In vitro</i>,<i>in silico</i>and<i>in vivo</i>study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss

Igor L. Chernyavsky, Richard Russell, Ruth Saunders, +13

European Respiratory Journal

NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma

Wing-Yan Heidi Wan, Fay Hollins, Louise Haste, +14

CHEST Journal

InflammationAsthmaEpithelial Ciliary DysfunctionNeutrophilic AsthmaLung Inflammation +7

Functional KCa3.1 Channels Regulate Steroid Insensitivity in Bronchial Smooth Muscle Cells

Latifa Chachi, Aarti Shikotra, S. Mark Duffy, +4

The Journal of Immunology

Validation of antibodies for the specific detection of human TRPA1

Harvinder Virk, Malgorzata Rekas, Michael Biddle, +6

Scientific Reports

CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma

Claire Emson, Sarah Diver, Latifa Chachi, +7

Respiratory Research

Pathophysiological regulation of lung function by the free fatty acid receptor FFA4

Rudi Prihandoko, Davinder Kaur, Coen Wiegman, +15

Science Translational Medicine

Bidirectional Counterregulation of Human Lung Mast Cell and Airway Smooth Muscle β2 Adrenoceptors

Rebecca J. Lewis, Latifa Chachi, Chris Newby, +2

The Journal of Immunology

AsthmaInflammatory Lung DiseaseLung InflammationMast Cell DisorderImmunology +18

Fibrocyte localisation to the ASM bundle in asthma: bidirectional effects on cell phenotype and behaviour

Ruth Saunders, Davinder Kaur, Dhananjay Desai, +5

Clinical & Translational Immunology