Yongxian Zhuang

Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27<sup>Kip1</sup> or p21<sup>Cip1</sup>

Yongxian Zhuang, W. Keith Miskimins · Journal of Molecular Signaling · 2008 · 241 citations · Full text

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Jia Yu, Bo Qin, Ann M. Moyer et al. · Journal of Clinical Investigation · 2018 · 204 citations · Full text

Breast Oncology, Engineering, Cancer Biology +17

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

Manling Xie, Yong Liu, Shunyi Zhao et al. · Nature Neuroscience · 2021 · 153 citations · Full text

Inflammation, Neurodegenerative Diseases, Medicine +11

Mechanisms by Which Low Glucose Enhances the Cytotoxicity of Metformin to Cancer Cells Both In Vitro and In Vivo

Yongxian Zhuang, Daniel Chan, Allison B. Haugrud et al. · PLoS ONE · 2014 · 148 citations · Full text

Cancer Cells Both, Cell Death, Metabolic Remodeling +19

Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells

Allison B. Haugrud, Yongxian Zhuang, Joseph D. Coppock et al. · Breast Cancer Research and Treatment · 2014 · 115 citations · Full text

Breast Oncology, Oncology, Medicine +10