D. J. PETTIBONE

Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of <i>N</i>-(1,3-Diphenyl-1<i>H</i>- pyrazol-5-yl)benzamides That Potentiate Receptor Function in Vivo

Craig W. Lindsley, David D. Wisnoski, William Leister et al. · Journal of Medicinal Chemistry · 2004 · 170 citations · Full text

Synaptic Transmission, Pharmacotherapy, Active Allosteric Modulators +20

Development of an intact cell reporter gene β-lactamase assay for G protein-coupled receptors for high-throughput screening

Priya Kunapuli, Richard W. Ransom, Kathy Murphy et al. · Analytical Biochemistry · 2003 · 84 citations

Signal Transduction, Protein Expression, Biochemistry +10

Challenges in the development of mGluR5 positive allosteric modulators: The discovery of CPPHA

Zhijian Zhao, David D. Wisnoski, Julie A. O’Brien et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 70 citations · Full text

Molecular Pharmacology, Molecular Physiology, Signal Transduction +8

Discovery of GlyT1 inhibitors with improved pharmacokinetic properties

S. E. Wolkenberg, Zhijian Zhao, David D. Wisnoski et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 22 citations · Full text

Medicinal Chemistry, Glyt1 Inhibitors, Medicine +6

Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors

Zhijian Zhao, William Leister, Julie A. O’Brien et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 21 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Potent Glyt1 Inhibitors +11