GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

Qin Wu, Wail Ba-Alawi, Geneviève Deblois, +26

Nature Communications

The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

Yupeng He, Sujatha Selvaraju, Michael L. Curtin, +34

Nature Chemical Biology

Protein FunctionSignal TransductionMolecular RegulationPrc2 ComplexMolecular Biology +5

A chemical toolbox for the study of bromodomains and epigenetic signaling

Qin Wu, David Heidenreich, Stanley Zhou, +17

Nature Communications

Epigenetic ChangeMolecular BiologyBromodomain Target ValidationEpigeneticsHuman Bromodomain Targets +19

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

Qin Wu, Yan Nie, Wail Ba-alawi, +26

Nature Chemical Biology

Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents

Xuliang Lang, Lulu Li, Qinsheng Sun, +6

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicineCell DeathPharmacological AgentAnti-cancer Agent +5

Multivalent Aptamer‐Based Lysosome‐Targeting Chimeras (LYTACs) Platform for Mono‐ or Dual‐Targeted Proteins Degradation on Cell Surface

Qiao Duan, Hao‐Ran Jia, Weichang Chen, +8

Advanced Science

Matairesinol exerts anti-inflammatory and antioxidant effects in sepsis-mediated brain injury by repressing the MAPK and NF-κB pathways through up-regulating AMPK

Qin Wu, Yuhua Wang, Qingfang Li

Aging

Molecular interaction study of flavonoid derivative 3d with human serum albumin using multispectroscopic and molecular modeling approach

Juntong Wei, Feng Jin, Qin Wu, +3

Talanta

Medicinal ChemistryMedicineBioanalysisRational Drug DesignFlavonoid Derivative 3D +10

Discovery of a chemical probe for PRDM9

Abdellah Allali‐Hassani, Magdalena M. Szewczyk, Danton Ivanochko, +27

Nature Communications

Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia

Chunbin Zou, Jin Li, Sheng Xiong, +8

Science Translational Medicine

Acute Lung InjuryLung InflammationApoptosisImmunologyCell Death +18