Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

Ryan D. Morin, Nathalie A. Johnson, Tesa Severson, +35

Nature Genetics

Tumor BiologyLymphoid NeoplasiaLarge B-cell LymphomasSomatic MutationsSomatic Variant +7

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

Ryan D. Morin, María Méndez-Lago, Andrew J. Mungall, +46

Nature

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

Damian Yap, Justin Chu, Tobias Berg, +14

Blood

Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma

Daisuke Ennishi, Aixiang Jiang, Merrill Boyle, +27

Journal of Clinical Oncology

Prognostic Significance of Diffuse Large B-Cell Lymphoma Cell of Origin Determined by Digital Gene Expression in Formalin-Fixed Paraffin-Embedded Tissue Biopsies

David W. Scott, Anja Mottok, Daisuke Ennishi, +18

Journal of Clinical Oncology

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma

Robert Kridel, Barbara Meissner, Sanja Rogić, +16

Blood

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Daisuke Ennishi, Katsuyoshi Takata, Wendy Béguelin, +23

Cancer Discovery

Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study

Robert Kridel, Fong Chun Chan, Anja Mottok, +29

PLoS Medicine

Gene Expression–Based Model Using Formalin-Fixed Paraffin-Embedded Biopsies Predicts Overall Survival in Advanced-Stage Classical Hodgkin Lymphoma

David W. Scott, Fong Chun Chan, Fangxin Hong, +21

Journal of Clinical Oncology

Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma

Jay Gunawardana, Fong Chun Chan, Adèle Telenius, +19

Nature Genetics

Lymphoid NeoplasiaHodgkin LymphomaSomatic VariantRecurrent Somatic MutationsPathology +4