Keiko Kakegawa

Design, synthesis, and structure–activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors

Makoto Kamata, Satoshi Endo, Mitsuo Yamamoto et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 19 citations · Full text

Medicinal Chemistry, Diversity Oriented Synthesis, Biochemistry +8

Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure–Activity Relationships of Novel 1-(Imidazo[1,2-<i>a</i>]pyridin-6-yl)pyridin-2(1<i>H</i>)-one Derivatives

Hideyuki Igawa, Masashi Takahashi, Keiko Kakegawa et al. · Journal of Medicinal Chemistry · 2016 · 19 citations · Full text

Chemical Biology, Structure–activity Relationships, Pharmaceutical Chemistry +18

Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test

Hideyuki Igawa, Masashi Takahashi, Minoru Ikoma et al. · Bioorganic & Medicinal Chemistry · 2016 · 14 citations · Full text

Medicinal Chemistry, Biochemistry, Functional Selectivity +9

Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition

Hideyuki Igawa, Masashi Takahashi, Mikio Shirasaki et al. · Bioorganic & Medicinal Chemistry · 2016 · 14 citations · Full text

Cyp3a4 Time-dependent Inhibition, Biochemistry, Functional Selectivity +8

Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore

Y. Tanaka, Masaki Seto, Keiko Kakegawa et al. · Journal of Medicinal Chemistry · 2022 · 13 citations · Full text