The histone deacetylase SIRT2 stabilizes Myc oncoproteins

Peiyuan Liu, Ning Xu, Alena Malyukova, +17

Cell Death and Differentiation

Histone ModificationsChromatinChromatin RemodelingEpigenetic ChangeHistone Deacetylase Sirt2 +4

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

Daniel R. Carter, Jayne Murray, Belamy B. Cheung, +36

Science Translational Medicine

TRIM16 Acts as an E3 Ubiquitin Ligase and Can Heterodimerize with Other TRIM Family Members

Jessica L. Bell, Alena Malyukova, Jessica K. Holien, +5

PLoS ONE

ChromatinProtein FunctionE3 Ubiquitin LigaseCan HeterodimerizeMedicine +12

An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

Zsuzsanna Nagy, Janith A. Seneviratne, Maxwell Kanikevich, +13

Nature Communications

TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells

Glenn M. Marshall, Jessica L. Bell, Jessica Koach, +12

Oncogene

Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression

Wayne Thomas, Jinbiao Chen, Y R Gao, +8

Oncogene

Gene Deletion DataCell RegulationMedicineN-myc Protein StabilityPathology +9

MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4

Chengyuan Xue, Denise Yu, Samuele Gherardi, +13

Oncotarget

Mycn-tfap4 AxisTranscription Factor Ap4Cancer BiologyGliomaTumor Biology +14

MYC phase separation selectively modulates the transcriptome

Junjiao Yang, Chan-I Chung, Jessica Koach, +11

Nature Structural & Molecular Biology

ChromatinTranscriptional RegulationMolecular RegulationNatural SciencesMyc Phase Separation +6

The retinoid signalling molecule, TRIM16, is repressed during squamous cell carcinoma skin carcinogenesis <i>in vivo</i> and reduces skin cancer cell migration <i>in vitro</i>

Belamy B. Cheung, Jessica Koach, Owen Tan, +17

The Journal of Pathology

The estrogen-responsive B box protein (EBBP) restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation

Anna Raif, Glenn M. Marshall, Jessica L. Bell, +9

Cancer Letters

ChromatinHistone AcetylationChromatin RemodelingMedicineRetinoid-resistant Cancer Cells +7