Jay M. Wendling

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

Mark E. Schnute, Matthew D. McReynolds, Tom Kasten et al. · Biochemical Journal · 2012 · 278 citations

Life Sciences, Cell Biology, Pharmacology +12

Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists

Xiao Hu, Yahong Wang, Ling-Yang Hao et al. · Nature Chemical Biology · 2015 · 230 citations

Life Sciences, Biochemistry, Pharmacology +11

A Novel Autotaxin Inhibitor Reduces Lysophosphatidic Acid Levels in Plasma and the Site of Inflammation

James K. Gierse, Atli Thorarensen, Konstantine Beltey et al. · Journal of Pharmacology and Experimental Therapeutics · 2010 · 230 citations

Medicine, Immunology, Pharmacology +13

Discovery of (3<i>S</i>,3a<i>R</i>)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2<i>H</i>-benzo[<i>g</i>]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy

Marvin J. Meyers, Graciela B. Arhancet, Susan L. Hockerman et al. · Journal of Medicinal Chemistry · 2010 · 91 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Identification and Characterization of a Novel Δ6/Δ5 Fatty Acid Desaturase Inhibitor As a Potential Anti-Inflammatory Agent

Mark G. Obukowicz, Amiram Raz, Paul D. Pyla et al. · Biochemical Pharmacology · 1998 · 58 citations

Life Sciences, Biochemistry, Pharmacology +12