Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, Fábio Camargo Abdalla, Hagai Abeliovich, +1232

Autophagy

MitophagyParticular Autophagy AssaysImmunologyCytoskeletonMultiple Assays +17

An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

Lotta Agholme, Tobias Lindström, Katarina Kågedal, +2

Journal of Alzheimer s Disease

Spreading of Neurodegenerative Pathology via Neuron-to-Neuron Transmission of  -Amyloid

Sangeeta Nath, Lotta Agholme, Firoz Roshan Kurudenkandy, +3

Journal of Neuroscience

Neurodegenerative DiseasesAlzheimer's DiseaseMedicineDementiaSynaptic Transmission +13

Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance

Jakob Domert, Sahana Bhima Rao, Lotta Agholme, +4

Neurobiology of Disease

Lysosomal Network Proteins as Potential Novel CSF Biomarkers for Alzheimer’s Disease

Andrea Armstrong, Niklas Mattsson, Hanna Appelqvist, +8

NeuroMolecular Medicine

Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production

Line S. Reinert, Ahmad Rashidi, Diana Tran, +18

Journal of Clinical Investigation

Viral PathogenesisImmunologyCell DeathImmune RegulationSimplex Encephalitis +17

HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

Chiranjeevi Bodda, Line S. Reinert, Stefanie Fruhwürth, +13

The Journal of Experimental Medicine

Hsv1 MutantsViral PathogenesisImmunologyInnate ImmunityHsv1 δDub +21

Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation

Petra Bergström, Lotta Agholme, Faisal Hayat Nazir, +16

Scientific Reports

App ProcessingBrain DevelopmentCerebral OrganoidNeurochemical BiomarkersAmyloid Precursor Protein +20

Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes

Jakob Domert, Christopher Sackmann, Emelie Severinsson, +4

PLoS ONE

Neurodegenerative DiseasesNatural SciencesCell TraffickingMolecular BiologyProtein Misfolding +10

Amyloid-β Secretion, Generation, and Lysosomal Sequestration in Response to Proteasome Inhibition: Involvement of Autophagy

Lotta Agholme, Martin Hallbeck, Eiríkur Benedikz, +2

Journal of Alzheimer s Disease

Cellular ViabilityMitophagyProtein SecretionProteasomeLysosomal Sequestration +21