Differentiation of hypothalamic-like neurons from human pluripotent stem cells

Liheng Wang, Kana Meece, Damian J. Williams, +13

Journal of Clinical Investigation

Adult Stem CellSonic HedgehogRegenerative MedicineStem CellsCell Signaling +15

Partially Redundant Enhancers Cooperatively Maintain Mammalian Pomc Expression Above a Critical Functional Threshold

Daniel D. Lam, Flávio S. J. de Souza, Sofía Nasif, +9

PLoS Genetics

Pomc TranscriptionMolecular RegulationGeneticsGene Regulatory NetworkSynaptic Signaling +25

β-Endorphin Antagonizes the Effects of α-MSH on Food Intake and Body Weight

Roxanne Dutia, Kana Meece, Shveta Dighe, +2

Endocrinology

NutritionFood IntakeCaloric RestrictionExperimental NutritionIntegrative Physiology +17

Functional heterogeneity of POMC neurons relies on mTORC1 signaling

Nicolas Saucisse, Wilfrid Mazier, Vincent Simon, +21

Cell Reports

Synaptic TransmissionMtorc1 ActivityNeurotransmitterFunctional HeterogeneityRapamycin Complex 1 +21

Clinical Utility of Plasma POMC and AgRP Measurements in the Differential Diagnosis of ACTH-Dependent Cushing's Syndrome

Gabrielle Page‐Wilson, Pamela U. Freda, Thomas P. Jacobs, +6

The Journal of Clinical Endocrinology & Metabolism

Cerebrospinal Fluid Levels of Leptin, Proopiomelanocortin, and Agouti-Related Protein in Human Pregnancy: Evidence for Leptin Resistance

Gabrielle Page‐Wilson, Elena Reitman-Ivashkov, Kana Meece, +4

The Journal of Clinical Endocrinology & Metabolism

Proopiomelanocortin, agouti-related protein, and leptin in human cerebrospinal fluid: correlations with body weight and adiposity

Gabrielle Page‐Wilson, Kana Meece, Anne White, +4

American Journal of Physiology-Endocrinology and Metabolism

Human Cerebrospinal FluidAdipokinesGastrointestinal Peptide HormoneObesityMetabolic Syndrome +22

PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons

Liheng Wang, Lina Sui, Sunil K. Panigrahi, +8

Stem Cell Reports

Continuous 24-Hour Leptin, Proopiomelanocortin, and Amino Acid Measurements in Human Cerebrospinal Fluid: Correlations With Plasma Leptin, Soluble Leptin Receptor, and Amino Acid Levels

Sharon L. Wardlaw, Charles Burant, Samuel Klein, +5

The Journal of Clinical Endocrinology & Metabolism

Evaluation of CSF and plasma biomarkers of brain melanocortin activity in response to caloric restriction in humans

Gabrielle Page‐Wilson, Kim T. Nguyen, Deniz Atalayer, +8

American Journal of Physiology-Endocrinology and Metabolism

NutritionNeuroendocrinologyCaloric RestrictionGastrointestinal Peptide HormoneObesity +27