MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

Kazuhiro Yamamoto, Hiroshi Okano, Wakako Miyagawa, +8

Matrix Biology

Human ChondrocytesPathologyCellular PhysiologyInflammationBone Morphogenic Protein +18

Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis

Mary-Clare Miller, Hugh B. Manning, Abhilash Jain, +8

Arthritis & Rheumatism

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases

Linda Troeberg, Kazunari Fushimi, Rama Khokha, +3

The FASEB Journal

Calcium Pentosan PolysulfateBiochemistryCapps InhibitionMedicineBone Morphogenic Protein +11

LRP‐1‐mediated endocytosis regulates extracellular activity of ADAMTS‐5 in articular cartilage

Kazuhiro Yamamoto, Linda Troeberg, Simone Dario Scilabra, +4

The FASEB Journal

Low Density Lipoprotein Receptor-related Protein Mediates Endocytic Clearance of Pro-MMP-2·TIMP-2 Complex through a Thrombospondin-independent Mechanism

Hervé Emonard, Georges Bellon, Linda Troeberg, +10

Journal of Biological Chemistry

ImmunologyPathologyLow DensityCancer BiologyTumor Biology +17

Proteases from <i>Trypanosoma brucei brucei</i>

Linda Troeberg, Robert N. Pike, Rory E. Morty, +3

European Journal of Biochemistry

Functional Differences of the Catalytic and Non-catalytic Domains in Human ADAMTS-4 and ADAMTS-5 in Aggrecanolytic Activity

Kazunari Fushimi, Linda Troeberg, Hiroyuki Nakamura, +2

Journal of Biological Chemistry

Production of cytokines, vascular endothelial growth factor, matrix metalloproteinases, and tissue inhibitor of metalloproteinases 1 by tenosynovium demonstrates its potential for tendon destruction in rheumatoid arthritis

Abhilash Jain, Jagdeep Nanchahal, Linda Troeberg, +2

Arthritis & Rheumatism

Interleukin‐1 Acts via the JNK‐2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes

Heba Ismail, Kazuhiro Yamamoto, Tonia L. Vincent, +3

Arthritis & Rheumatology

Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4)

Kazuhiro Yamamoto, Kathryn Owen, Andrew E. Parker, +5

Journal of Biological Chemistry

Proteinlipid InteractionSclerostinImmunologyThrombospondin Motifs-4Molecular Biology +27