Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules

W. You, Dante Rotili, Tie‐Mei Li, +6

Angewandte Chemie International Edition

Sirtuin 6Sirt6 Catalytic CoreProtein FunctionSirt6 ActivatorsProtein Assembly +13

Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation

Peggie Cheung, Steven Schaffert, Sarah E. Chang, +17

Nature Immunology

ChromatinTranscriptional RegulationSignal TransductionSignaling PathwayCell Regulation +8

The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability

Silvana Paredes, Maria Angulo‐Ibáñez, Luisa Tasselli, +4

Journal of Biological Chemistry

Mammalian Cellular SenescenceChromatinGenome InstabilityChromatin RemodelingMedicine +7

E2F Transcription Factor 1 Regulates Cellular and Organismal Senescence by Inhibiting Forkhead Box O Transcription Factors

Qi Xie, Shengyi Peng, Tao Li, +8

Journal of Biological Chemistry

Reductive StressTranscriptional RegulationFoxo3 Protein StabilityDevelopmental BiologyCell Regulation +12

Correction: Characterization of PUD-1 and PUD-2, Two Proteins Up-Regulated in a Long-Lived daf-2 Mutant

Yue‐He Ding, Yunguang Du, S.C. Luo, +8

PLoS ONE

Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue

Muhammad Zoabi, Lichao Zhang, Tie‐Mei Li, +3

Journal of Biological Chemistry

Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation

Tie‐Mei Li, Jing Ren, Dylan Husmann, +3

Scientific Reports

Absolute Quantification of a Steroid Hormone that Regulates Development in <i>Caenorhabditis elegans</i>

Tie‐Mei Li, Jie Chen, Xiangke Li, +6

Analytical Chemistry

GeneticsBiological Mass SpectrometryMolecular BiologyMetabolomic ProfilingSteroid Hormone +31

Quantitative Proteomics of Sleep-Deprived Mouse Brains Reveals Global Changes in Mitochondrial Proteins

Jing Ren, Meijun Zhang, Tie‐Mei Li, +5

PLoS ONE

Molecular BiologyNeurochemical BiomarkersSleep LossProlonged Sleep DeprivationSocial Sciences +18

Mammalian SIRT6 Represses Invasive Cancer Cell Phenotypes through ATP Citrate Lyase (ACLY)-Dependent Histone Acetylation

Wei Zheng, Luisa Tasselli, Tie‐Mei Li, +1

Genes

Histone ModificationsMolecular BiologyCancer BiologyEpigeneticsTumor Biology +20