Advanced age results in a diminished endothelial glycocalyx

Daniel R. Machin, Samuel I. Bloom, Robert A. Campbell, +5

American Journal of Physiology-Heart and Circulatory Physiology

Advanced Age ResultsAdvanced AgeAgingEngineeringSurgery +19

A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD⁺-Dependent Enzymes

Lik Hang Yuen, Srikanta Dana, Yu Liu, +7

Journal of the American Chemical Society

Endothelial cell telomere dysfunction induces senescence and results in vascular and metabolic impairments

Samuel I. Bloom, Yu Liu, Jordan R. Tucker, +7

Aging Cell

Aging results in DNA damage and telomere dysfunction that is greater in endothelial versus vascular smooth muscle cells and is exacerbated in atheroprone regions

Samuel I. Bloom, Jordan R. Tucker, Jisok Lim, +4

GeroScience

Dna DamageAgingLongevityGeneticsPhysiology +9

Effects of a combined protein and antioxidant supplement on recovery of muscle function and soreness following eccentric exercise

Stephen J. Ives, Samuel I. Bloom, Alexs A. Matias, +10

Journal of the International Society of Sports Nutrition

Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress

R. Garrett Morgan, Ashley E. Walker, Daniel W. Trott, +11

Journal of Molecular and Cellular Cardiology

Vascular PhenotypeAgingLongevityMedicineSenescence Signaling +8

Glycocalyx-targeted therapy ameliorates age-related arterial dysfunction

Daniel R. Machin, Daniel W. Trott, Venkateswara R. Gogulamudi, +5

GeroScience

Translational MedicineVascular DiseaseAgingCardiovascular DiseaseGlycocalyx-targeted Therapy +6

T cells mediate cell non‐autonomous arterial ageing in mice

Daniel W. Trott, Daniel R. Machin, Tam T. T. Phuong, +6

The Journal of Physiology

Endothelial cell‐specific reduction in mTOR ameliorates age‐related arterial and metabolic dysfunction

Md Torikul Islam, Shelby A. Hall, Tavia Dutson, +7

Aging Cell

High‐fat diet induced obesity and age influence the telomere shelterin complex and telomerase gene expression in mouse adipose tissue

Samuel I. Bloom, Andrei Tuluca, Stephen J. Ives, +1

Physiological Reports

AgingMetabolic DisorderShelterin ComplexBiogerontologyCaloric Restriction +16