Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator

Kenji Maeda, Haruhiko Sugino, Hitomi Akazawa, +14

Journal of Pharmacology and Experimental Therapeutics

Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration

Yuta Ohgi, Takashi Futamura, Tetsuro Kikuchi, +1

Pharmacology Biochemistry and Behavior

PsychoneuroimmunologyPsychiatryMedicinePsychotropic MedicationLipopolysaccharide Administration +9

Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice

Haruhiko Sugino, Takashi Futamura, Yasuhide Mitsumoto, +2

Progress in Neuro-Psychopharmacology and Biological Psychiatry

InflammationPsychiatryMedicinePsychotropic MedicationLipopolysaccharide-treated Mice +7

Cannabidivarin is anticonvulsant in mouse and rat

A.G. Hill, M. Mercier, TDM Hill, +8

British Journal of Pharmacology

Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients

Takashi Futamura, Kazuhiko Toyooka, Shuji Iritani, +7

Molecular Psychiatry

Schizophrenic PatientsEpidermal Growth FactorPsychiatryHuman GrowthPathology +6

Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis

Noriko Yoshimi, Takashi Futamura, Sarah E. Bergen, +11

Molecular Psychiatry

Mitochondrial DysfunctionCerebrospinal Fluid MetabolomicsNeurophysiological BiomarkersNeurochemical BiomarkersCsf Levels +15

Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development

Takashi Futamura, Akiyoshi Kakita, Manavu Tohmi, +3

Molecular Psychiatry

NeuropsychologyCognitive ScienceDevelopmental BiologyNeonatal PerturbationDevelopmental Cognitive Neuroscience +13

Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder

Noriko Yoshimi, Takashi Futamura, Keiji Kakumoto, +7

BBA Clinical

Antidepressant effects of combination of brexpiprazole and fluoxetine on depression-like behavior and dendritic changes in mice after inflammation

Min Ma, Qian Ren, Chun Yang, +6

Psychopharmacology

Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: Role of BDNF-TrkB signaling

Min Ma, Qian Ren, Chun Yang, +6

Scientific Reports