Charge variants characterization of a monoclonal antibody by ion exchange chromatography coupled on-line to native mass spectrometry: Case study after a long-term storage at +5 °C

Y. Leblanc, C. Ramon, Nicolas Bihoreau, +1

Journal of Chromatography B

Charge Variants CharacterizationAged Monoclonal AntibodyImmunologyBiological Mass SpectrometryBioanalysis +17

Middle-up analysis of monoclonal antibodies after combined IgdE and IdeS hinge proteolysis: Investigation of free sulfhydryls

Valegh Faid, Y. Leblanc, Nicolas Bihoreau, +1

Journal of Pharmaceutical and Biomedical Analysis

Immunocytochemical TechniqueImmunologyGlycobiologyMabs StructureProtein Purification +15

Characterization of Human Serum Albumin isoforms by ion exchange chromatography coupled on-line to native mass spectrometry

Y. Leblanc, Nicolas Bihoreau, Guillaume Chevreux

Journal of Chromatography B

BiochemistryGas ChromatographyMedicineNatural SciencesBioanalysis +10

A generic method for intact and subunit level characterization of mAb charge variants by native mass spectrometry

Y. Leblanc, Valegh Faid, Matthew Lauber, +3

Journal of Chromatography B

BiochemistryNatural SciencesMedicineBioanalysisMass Spectrometry +9

LC–MS analysis of polyclonal IgGs using IdeS enzymatic proteolysis for oxidation monitoring

Y. Leblanc, Marie Romanin, Nicolas Bihoreau, +1

Journal of Chromatography B

EngineeringImmunotoxicologyImmunologyBiological Mass SpectrometryIdes Treatment +25

Glycation of polyclonal IgGs: Effect of sugar excipients during stability studies

Y. Leblanc, Nicolas Bihoreau, M. Jube, +3

European Journal of Pharmaceutics and Biopharmaceutics

EngineeringGlycobiologyPolysaccharideNon-reducing SugarsStability Studies +19

Investigation of monoclonal antibody dimers in a final formulated drug by separation techniques coupled to native mass spectrometry

Grégory Rouby, Nguyet Thuy Tran, Y. Leblanc, +2

mAbs

Human serum albumin presents isoform variants with altered neonatal Fc receptor interactions

Y. Leblanc, Marie Berger, Alexander Seifert, +2

Protein Science

C-terminal lysine clipping of IgG1: impact on binding to human FcγRIIIa and neonatal Fc receptors

Valegh Faid, Y. Leblanc, Marie Berger, +3

European Journal of Pharmaceutical Sciences

C-terminal Lysine ClippingImmunologyImmune RegulationImmunodominanceGlycobiology +25

Biochemical characterization of <scp>LR</scp>769, a new recombinant factor VIIa bypassing agent produced in the milk of transgenic rabbits

Guillaume Chevreux, Noel De Tilly, Y. Leblanc, +5

Haemophilia