Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2.

Louis Buscail, Nathalie Delesque, J.P. Estève, +7

Proceedings of the National Academy of Sciences

ImmunologyMolecular PharmacologySignaling PathwayReceptor Tyrosine KinaseTyrosine Phosphatase +19

P2Y12, a New Platelet ADP Receptor, Target of Clopidogrel

Pierre Savi, Catherine Labouret, Nathalie Delesque, +3

Biochemical and Biophysical Research Communications

ThrombopoiesisThrombosisPlatelet Aggregation InhibitorsMolecular PharmacologyBlood Platelet +5

The Tyrosine Phosphatase SHP-1 Associates with the sst2 Somatostatin Receptor and Is an Essential Component of sst2-mediated Inhibitory Growth Signaling

Frédéric Lopez, Jean‐Pierre Estève, Louis Buscail, +6

Journal of Biological Chemistry

Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5

Pierre Cordelier, Jean‐Pierre Estève, Corinne Bousquet, +6

Proceedings of the National Academy of Sciences

sst2 Somatostatin Receptor Mediates Negative Regulation of Insulin Receptor Signaling through the Tyrosine Phosphatase SHP-1

Corinne Bousquet, Nathalie Delesque, Frédéric Lopez, +6

Journal of Biological Chemistry

sst2 somatostatin receptor expression reverses tumorigenicity of human pancreatic cancer cells.

Nathalie Delesque, Louis Buscail, J.P. Estève, +6

PubMed

Pancreatic CancerSst2 DefectCell SignalingSst2 Gene ExpressionMedicine +9

Gene Therapy for Pancreatic Carcinoma: Local and Distant Antitumor Effects after Somatostatin Receptor sst2 Gene Transfer

Philippe Rochaix, Nathalie Delesque, J.P. Estève, +5

Human Gene Therapy

Tumor BiologyPancreatic CancerOncogenic AgentMedicineImmunology +13

Induction of a negative autocrine loop by expression of sst2 somatostatin receptor in NIH 3T3 cells.

Isabelle Rauly, Nathalie Saint‐Laurent, Nathalie Delesque, +4

Journal of Clinical Investigation

T-regulatory CellImmunologyPathologyImmunologic MechanismSst2-induced Inhibition +19

<i>N</i>-[6-(4-Butanoyl-5-methyl-1<i>H</i>-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1<i>H</i>-indole-3-carboxamide (SAR216471), a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist

Christophe Boldron, Angélina Besse, Marie-Françoise Bordes, +21

Journal of Medicinal Chemistry

Acting P2y12 AntagonistImmunologyPharmacotherapyPharmaceutical ChemistryAdp-induced Platelet Aggregation +20

Up-regulation of somatostatin receptors by epidermal growth factor and gastrin in pancreatic cancer cells.

Célia Vidal, Isabelle Rauly, M. Zeggari, +5

Molecular Pharmacology