Reevaluation of the Mechanism of the Amination of Aryl Halides Catalyzed by BINAP-Ligated Palladium Complexes

Shashank Shekhar, Per Ryberg, John F. Hartwig, +4

Journal of the American Chemical Society

Chemical EngineeringCross-coupling ReactionEngineeringNmr SpectroscopyAlkene Metathesis +11

Investigations of Pd-Catalyzed ArX Coupling Reactions Informed by Reaction Progress Kinetic Analysis

Jinu S. Mathew, Hiroshi Iwamura, Fernando E. Valera, +3

The Journal of Organic Chemistry

Chemical EngineeringCross-coupling ReactionEngineeringBiochemistryGlobal Kinetic Analysis +13

Multkilogram Scale-Up of a Reductive Alkylation Route to a Novel PARP Inhibitor

Adam T. Gillmore, Matthew Badland, Clare L. Crook, +12

Organic Process Research & Development

Pharmaceutical ChemistryKg ScaleOvarian CancerMedicinal ChemistryDiversity Oriented Synthesis +16

Reaction Calorimetry as a Tool for Understanding Reaction Mechanisms:  Application to Pd-Catalyzed Reactions

Antonio C. Ferretti, Jinu S. Mathew, Donna G. Blackmond

Industrial & Engineering Chemistry Research

EngineeringDifferential Scanning CalorimetryOrganic ChemistryPd-catalyzed ReactionsComputational Chemistry +14

Mechanistic Inferences Derived from Competitive Catalytic Reactions: Pd(binap)‐Catalyzed Amination of Aryl Halides

Antonio C. Ferretti, Jinu S. Mathew, Ian W. Ashworth, +3

Advanced Synthesis & Catalysis

Aryl HalidesCompetitive NetworkCross-coupling ReactionEngineeringCompetitive Reactions +9

The Lactol Route to Fesoterodine: An Amine-Promoted Friedel–Crafts Alkylation on Commercial Scale

Olivier Dirat, Andrew J. Bibb, Colin M. Burns, +12

Organic Process Research & Development

Commercial ScaleDerivativesEngineeringLactol RouteAmine-promoted Friedel–crafts Alkylation +11

Comprehensive Kinetic Screening of Palladium Catalysts for Heck Reactions

Donna G. Blackmond, Andreas Pfaltz, Thomas Schultz, +3

Synlett

Comprehensive Kinetic ScreeningInitial ReactivityCross-coupling ReactionBiochemistryNatural Sciences +7

A Simplified Process for the Manufacture of Imagabalin Hydrochloride (PD-0332334), an α2δ-Ligand for the Treatment of Generalised Anxiety Disorder

Melissa Birch, Stephen Challenger, Jean-Philippe Crochard, +10

Organic Process Research & Development

Simplified ProcessEngineeringPsychotropic MedicationPsychopharmacologyEfficient Two-step Process +22

Development of the Synthetic Route to PF-06878031 Part 1: Selective Alkylation Route

Oriana Brea, Julia Buck, Nessa Carson, +14

Organic Process Research & Development