Alex H. Y. Chan

Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity

Alex H. Y. Chan, Imam Fathoni, Terence C. S. Ho et al. · RSC Medicinal Chemistry · 2022 · 38 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +11

Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues

Alex H. Y. Chan, Terence C. S. Ho, Imam Fathoni et al. · ACS Medicinal Chemistry Letters · 2023 · 20 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

Furan-based inhibitors of pyruvate dehydrogenase: SAR study, biochemical evaluation and computational analysis

Alex H. Y. Chan, Terence C. S. Ho, Daniel R. Parle et al. · Organic & Biomolecular Chemistry · 2023 · 15 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +15

ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma

Yuting Lu, Jana Trávníčková, Mihaly Badonyi et al. · Cell Reports · 2024 · 15 citations · Full text

Medicine, Molecular Biology, Oncology +17

Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation

Alex H. Y. Chan, Terence C. S. Ho, Rimsha Irfan et al. · Bioorganic Chemistry · 2023 · 13 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16