James Garnsey

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen et al. · Nature · 2009 · 2K citations

Medicine, Medicinal Chemistry, Oncology +8

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB–dependent lymphoma

Michael A. Milhollen, Tary Traore, Jennifer Adams-Duffy et al. · Blood · 2010 · 323 citations · Full text

Medicine, Molecular Biology, Oncology +11

Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia

Ronan Swords, Kevin R. Kelly, Peter G. Smith et al. · Blood · 2010 · 277 citations · Full text

Medicine, Oncology, Pharmacology +7

A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models

Eric S. Lightcap, Pengfei Yu, Stephen Grossman et al. · Science Translational Medicine · 2021 · 140 citations · Full text

Medicine, Immunology, Oncology +13

KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism

Nibedita Chattopadhyay, Allison Berger, Erik Koenig et al. · PLoS ONE · 2015 · 18 citations · Full text

Medicine, Oncology, Pharmacology +13