The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: A comparison of primary human hepatocytes and OATP-transfected HEK293 cells

Andreas Fischer, Stefan J. Hoeger, Kerstin Stemmer, +4

Toxicology and Applied Pharmacology

AllergyOatp-transfected Hek293 CellsMedicineLiver PhysiologyOrganic Anion +9

Oatp-associated uptake and toxicity of microcystins in primary murine whole brain cells

Daniel Feurstein, Klaus K. Holst, Andreas Fischer, +1

Toxicology and Applied Pharmacology

NeurophysiologyOatp-associated UptakeMedicinePhysiologyNeuropharmacology +5

Inhibition of TGF-β induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase

Torsten Dunkern, Daniel Feurstein, Giovanni A. Rossi, +2

European Journal of Pharmacology

Molecular PharmacologyAntifibrotic TherapyMolecular PhysiologyFibrosisLung Inflammation +8

Investigation of Microcystin Congener–Dependent Uptake into Primary Murine Neurons

Daniel Feurstein, Julia Kleinteich, Alexandra H. Heussner, +2

Environmental Health Perspectives

Microcystin Congener– and Concentration-Dependent Induction of Murine Neuron Apoptosis and Neurite Degeneration

Daniel Feurstein, Kerstin Stemmer, Julia Kleinteich, +2

Toxicological Sciences

Simultaneous Detection of 14 Microcystin Congeners from Tissue Samples Using UPLC- ESI-MS/MS and Two Different Deuterated Synthetic Microcystins as Internal Standards

Stefan Altaner, Jonathan Puddick, Valérie Fessard, +4

Toxins

Simultaneous DetectionCyanobacterial MicrocystinsBiological Mass SpectrometryPathologyMicrocystin Congeners +16

Identification of an EGFRvIII-JNK2-HGF/c-Met–Signaling Axis Required for Intercellular Crosstalk and Glioblastoma Multiforme Cell Invasion

Vanessa Saunders, M. Lafitte, Isabel Adrados, +6

Molecular Pharmacology

Mechanism of Oxidative Stress-Induced ASK1-Catalyzed MKK6 Phosphorylation

Emmanuel Sturchler, Daniel Feurstein, Patricia McDonald, +1

Biochemistry

Mkk6 Binding AffinityReductive StressSignal TransductionAsk1 Catalytic EfficiencyBiochemistry +13

Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin α2/β1 heterodimer

Emmanuel Sturchler, Daniel Feurstein, Weimin Chen, +2

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Abstract OT1-03-02: MP0274-CP101: A phase 1, first-in-human, single-arm, multi-center, open-label, dose escalation study to assess safety, tolerability, and pharmacokinetics of MP0274 in patients with advanced HER2-positive solid tumors

Richard D. Baird, Aurelius Omlin, Joachim Kiemle-Kallee, +8

Cancer Research

Statistical MethodsMedicineMetronomic TherapyPharmacologyImmunology +12