Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Han Gao, Matt C. Danzi, Claire Choi, +8

Cell Reports

Macrophagic Tnfr2Tnf Receptor 2ImmunologyImmune RegulationCell Death +16

Icariin improves osteoporosis, inhibits the expression of PPARγ, C/EBPα, FABP4 mRNA, N1ICD and jagged1 proteins, and increases Notch2 mRNA in ovariectomized rats

Hengrui Liu, Yingquan Xiong, Xiaofeng Zhu, +10

Experimental and Therapeutic Medicine

Notch2 MrnaBone TissueOsteoporosisInflammationMolecular Pharmacology +15

MCPIP1 restrains mucosal inflammation by orchestrating the intestinal monocyte to macrophage maturation via an ATF3-AP1S2 axis

Huiying Lu, Cui Zhang, Wei Wu, +13

Gut

Mitochondrial DNA Double-Strand Breaks in Oligodendrocytes Cause Demyelination, Axonal Injury, and CNS Inflammation

Pernille M. Madsen, Milena Pinto, Shreyans Patel, +10

Journal of Neuroscience

The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling

Boyu Zhang, Qingxin Liu, Weijie Wen, +12

Cell Discovery

Chd6 PromoterCancer BiologyEpigeneticsTumor BiologyTranscriptional Regulation +16

Fibrotic scar after experimental autoimmune encephalomyelitis inhibits oligodendrocyte differentiation

Stephanie L. Yahn, Jiajun Li, Irene Goo, +3

Neurobiology of Disease

PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis

Yan Geng, Lin Li, Jie Yan, +10

Nature Communications

Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling

Bettina Hjelm Clausen, Matilda Degn, Mithula Sivasaravanaparan, +15

Scientific Reports

Integrative multi-omics deciphers the spatial characteristics of host-gut microbiota interactions in Crohn’s disease

Xiang Gao, Ruicong Sun, Na Jiao, +13

Cell Reports Medicine

Chronic Inflammatory DiseasesDysbiosisHost-microbe InteractionsImmunologyPathology +18

TNFR2 Signaling Regulates the Immunomodulatory Function of Oligodendrocyte Precursor Cells

Haritha L. Desu, Placido Illiano, James S. Choi, +4

Cells

Immune RegulationImmunologyCell DeathSoltnf SignalsCell Proliferation +28