Proline Modulates the Trypanosoma cruzi Resistance to Reactive Oxygen Species and Drugs through a Novel D, L-Proline Transporter

Melisa Sayé, Mariana R. Miranda, Fabio di Girolamo, +2

PLoS ONE

Proline TransporterAntiparasitic AgentPathologyVisceral LeishmaniasisProline Metabolism +18

Trypanocidal Effect of Isotretinoin through the Inhibition of Polyamine and Amino Acid Transporters in Trypanosoma cruzi

Chantal Reigada, Edward A. Valera-Vera, Melisa Sayé, +4

PLoS neglected tropical diseases

Resveratrol inhibits Trypanosoma cruzi arginine kinase and exerts a trypanocidal activity

Edward A. Valera-Vera, Melisa Sayé, Chantal Reigada, +4

International Journal of Biological Macromolecules

Trypanocidal ActivityAfrican TrypanosomiasisMedicineSystems BiologyPharmacology +2

Cationic Amino Acid Uptake Constitutes a Metabolic Regulation Mechanism and Occurs in the Flagellar Pocket of Trypanosoma cruzi

Mariana R. Miranda, Melisa Sayé, León A. Bouvier, +3

PLoS ONE

Flagellar PocketMolecular BiologyArginine KinaseProtein SynthesisBioenergetics +18

Trypanosoma cruzi Polyamine Transporter: Its Role on Parasite Growth and Survival Under Stress Conditions

Chantal Reigada, Melisa Sayé, Edward A. Valera-Vera, +5

The Journal of Membrane Biology

BiologyParasitic DiseaseAfrican TrypanosomiasisParasitic ProtozoaMalaria +8

Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069

Melisa Sayé, Lucrecia Gauna, Edward A. Valera-Vera, +3

PLoS neglected tropical diseases

Repurposing of terconazole as an anti Trypanosoma cruzi agent

Chantal Reigada, Melisa Sayé, Edward A. Valera-Vera, +2

Heliyon

Arginine kinase in Phytomonas, a trypanosomatid parasite of plants

Gaspar E. Cánepa, Carolina Carrillo, Mariana R. Miranda, +2

Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology

BiologyParasitic ProtozoaAfrican TrypanosomiasisPlant PathologyArginine Kinase +3

In silico repositioning of etidronate as a potential inhibitor of the Trypanosoma cruzi enolase

Edward A. Valera-Vera, Melisa Sayé, Chantal Reigada, +2

Journal of Molecular Graphics and Modelling

Silico RepositioningBiochemistryParasitic ProtozoaMedicineNatural Sciences +7

Evaluation of proline analogs as trypanocidal agents through the inhibition of a Trypanosoma cruzi proline transporter

Melisa Sayé, Lucía Fargnoli, Chantal Reigada, +2

Biochimica et Biophysica Acta (BBA) - General Subjects

Drug TargetingBiochemistryAntiparasitic AgentMedicineParasitic Protozoa +7