Daniel Brigham

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

Patrick P. Zarrinkar, Ruwanthi N. Gunawardane, Merryl Cramer et al. · Blood · 2009 · 644 citations · Full text

Medicine, Medicinal Chemistry, Oncology +14

Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts

Andiliy Lai, Mehmet Kahraman, Steven P. Govek et al. · Journal of Medicinal Chemistry · 2015 · 247 citations · Full text

Medicine, Oncology, Pharmacology +13

In vivo characterization of the psa genes from Streptococcus pneumoniae in multiple models of infection

Andrea Marra, Stacey Lawson, Jyoti Asundi et al. · Microbiology · 2002 · 121 citations

Life Sciences, Genetics, Microbiology +17

Differential Fluorescence Induction Analysis of <i>Streptococcus pneumoniae</i> Identifies Genes Involved in Pathogenesis

Andrea Marra, Jyoti Asundi, Magdalena Bartilson et al. · Infection and Immunity · 2002 · 99 citations · Full text

Life Sciences, Microbiology, Molecular Biology +17

Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927

Mehmet Kahraman, Steven P. Govek, Johnny Nagasawa et al. · ACS Medicinal Chemistry Letters · 2018 · 76 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16