Steven P. Govek

Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts

Andiliy Lai, Mehmet Kahraman, Steven P. Govek et al. · Journal of Medicinal Chemistry · 2015 · 244 citations · Full text

Breast Oncology, Chemoprevention Strategy, Pharmacotherapy +16

Catalytic Asymmetric Synthesis of Quaternary Carbon Centers. Exploratory Studies of Intramolecular Heck Reactions of (<i>Z</i>)-α,β-Unsaturated Anilides and Mechanistic Investigations of Asymmetric Heck Reactions Proceeding via Neutral Intermediates

Atsuyuki Ashimori, Benoit Bachand, Michael A. Calter et al. · Journal of the American Chemical Society · 1998 · 183 citations

Catalytic Asymmetric Synthesis, Monomeric Pd−binap, Engineering +17

The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

James D. Joseph, Beatrice Darimont, Wei Zhou et al. · eLife · 2016 · 117 citations · Full text

Diverse Models, Breast Oncology, Erα Signaling +16

Total Synthesis of Asperazine

Steven P. Govek, Larry E. Overman · Journal of the American Chemical Society · 2001 · 85 citations

Chemical Measurement, Donut Icon, Altmetric Attention Score +8

Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927

Mehmet Kahraman, Steven P. Govek, Johnny Nagasawa et al. · ACS Medicinal Chemistry Letters · 2018 · 74 citations · Full text