Xiaoyu Lin

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

Emily J. Faivre, Keith F. McDaniel, Daniel H. Albert et al. · Nature · 2020 · 404 citations

Life Sciences, Molecular Biology, Oncology +10

DeepST: identifying spatial domains in spatial transcriptomics by deep learning

Chang Xu, Xiyun Jin, Songren Wei et al. · Nucleic Acids Research · 2022 · 320 citations · Full text

Life Sciences, Cancer Biology, Oncology +17

‘Seed’ analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737

Xiaoyu Lin, Susan E. Morgan-Lappe, Xiaoli Huang et al. · Oncogene · 2006 · 228 citations

Life Sciences, Cancer Biology, Molecular Biology +17

The Bcl-2/Bcl-XL/Bcl-w Inhibitor, Navitoclax, Enhances the Activity of Chemotherapeutic Agents <i>In Vitro</i> and <i>In Vivo</i>

Jun Chen, Sha Jin, Vivek Abraham et al. · Molecular Cancer Therapeutics · 2011 · 149 citations

Medicine, Oncology, Pharmacology +14

Discovery of <i>N</i>-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor

Keith F. McDaniel, Le Wang, Todd Soltwedel et al. · Journal of Medicinal Chemistry · 2017 · 137 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12