Design, synthesis and Structure–activity relationship studies of new thiazole-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

Zheng Li, Qianqian Qiu, Xue Xu, +6

European Journal of Medicinal Chemistry

BiochemistryMedicineDiabetesType 2Pharmacological Agent +4

Injectable self-assembled peptide hydrogels for glucose-mediated insulin delivery

Mian Fu, Chen‐Yu Zhang, Yuxuan Dai, +5

Biomaterials Science

Tissue EngineeringEngineeringPeptide EngineeringBiofabricationPeptide Therapeutics +16

Pro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane

Yuxuan Dai, Xingguang Cai, Wei Shi, +7

Amino Acids

MedicinePeptide LibraryPeptide EngineeringImmunologyPeptide Therapeutic +5

Design, Synthesis, and Pharmacological Characterization of<i>N</i>-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1<i>H</i>)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance

Qianqian Qiu, Baomin Liu, Jian Cui, +10

Journal of Medicinal Chemistry

Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance

Qianqian Qiu, Wei Shi, Zheng Li, +6

Journal of Medicinal Chemistry

Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

Zheng Li, Miaobo Pan, Xin Su, +6

Bioorganic & Medicinal Chemistry

Metabolic SyndromeNovel Pyrrole-based ScaffoldBiochemistryMedicineDiabetes +5

Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors

Yuxiang Wu, Miaobo Pan, Yuxuan Dai, +6

Bioorganic & Medicinal Chemistry

Pharmaceutical ScienceLbm-a5 DerivativesBiochemistryMedicineRational Drug Design +6

Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

Zheng Li, Chunxia Liu, Xue Xu, +10

European Journal of Medicinal Chemistry

Metabolic SyndromeDiabetes ManagementBiochemistryMedicineInsulin Management +6

Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells

Mutta Kairuki, Qianqian Qiu, Miaobo Pan, +6

Bioorganic & Medicinal Chemistry

BiochemistryMedicineP-glycoprotein InhibitorsPharmacotherapyAntimicrobial Chemotherapy +5

Characterization of l-glutamate and kainate binding sites in the brain of a freshwater fish, Telapilia monsanbica

C.-K. Tong, Miaobo Pan, Yen‐Chung Chang

Neuroscience

BiologyTelapilia MonsanbicaHealth SciencesNeurophysiologyNeuroanatomy +11