Geniposide protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via up-regulation of miR-145-5p

Shaolong Ma, Chao Zhang, Ziyan Zhang, +3

Artificial Cells Nanomedicine and Biotechnology

Injectable self-assembled peptide hydrogels for glucose-mediated insulin delivery

Mian Fu, Chen‐Yu Zhang, Yuxuan Dai, +5

Biomaterials Science

Tissue EngineeringEngineeringPeptide EngineeringBiofabricationPeptide Therapeutics +16

Pro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane

Yuxuan Dai, Xingguang Cai, Wei Shi, +7

Amino Acids

MedicinePeptide LibraryPeptide EngineeringImmunologyPeptide Therapeutic +5

Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitors

Weijie Gu, Yuxuan Dai, Qiang Hao, +5

Bioorganic Chemistry

Pyridine DerivativesMedicinal ChemistryMedicineNatural SciencesRational Drug Design +6

Development of cell-permeable peptide-based PROTACs targeting estrogen receptor α

Yuxuan Dai, Yue Na, Junni Gong, +5

European Journal of Medicinal Chemistry

Hormonal ReceptorPeptide TherapeuticEstrogen Receptor αPeptide SciencePeptide Therapeutics +2

A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects

Jie Zhou, Xingguang Cai, Xun Huang, +7

European Journal of Medicinal Chemistry

ObesityMetabolic SyndromeDiabetes ManagementMedicineDiabetes-protective Effects +9

Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance

Qianqian Qiu, Wei Shi, Zheng Li, +6

Journal of Medicinal Chemistry

Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

Zheng Li, Miaobo Pan, Xin Su, +6

Bioorganic & Medicinal Chemistry

Metabolic SyndromeNovel Pyrrole-based ScaffoldBiochemistryMedicineDiabetes +5

Synthesis and anti-cancer evaluation of folic acid-peptide- paclitaxel conjugates for addressing drug resistance

Yuxuan Dai, Xingguang Cai, Xinzhou Bi, +7

European Journal of Medicinal Chemistry

Medicinal ChemistryHealth SciencesPolymer-drug ConjugateMedicinePharmacotherapy +7

Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists

Xuekun Wang, Tianxiao Zhao, Baowei Yang, +7

Bioorganic & Medicinal Chemistry

Molecular PharmacologyLipid SynthesisBiochemistryOmega-3 Fatty AcidMedicine +6