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Amanda Jack, Luke S. Ferro, Michael J. Trnka, +7

PLoS Biology

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Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy

Chih-Yuan Chuang, Scott E. Collibee, Luke Ashcraft, +15

Journal of Medicinal Chemistry

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection

Scott B. Biering, Sylvia A. Sarnik, Eleanor Wang, +46

Nature Genetics

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Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis

Joseph M. Hendricks, Cody E. Doubravsky, Eddie Wehri, +10

Cell chemical biology

Diverse Fsp1 InhibitorsTumor BiologyMedicineFerroptosisTumor Targeting +9

An intranasal ASO therapeutic targeting SARS-CoV-2

Chi Zhu, Justin Y. Lee, Jia Z. Woo, +19

Nature Communications

Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy

James J. Hartman, Darren T. Hwee, Julien Robert‐Paganin, +17

Nature Cardiovascular Research

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA

Amanda Jack, Luke S. Ferro, Michael J. Trnka, +6

Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2

Scott B. Biering, Erik Van Dis, Eddie Wehri, +19

ACS Infectious Diseases

Inflammatory Lung DiseaseClinical CompoundsAntiviral ActivityMedicineAntiviral Drug Development +12

Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells

Eddie Wehri, Erik Van Dis, Scott B. Biering, +19

Scientific Reports

Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells

Xammy Nguyenla, Eddie Wehri, Erik Van Dis, +7

Submaximal Remdesivir ConcentrationsSars Coronavirus 2Antiviral CompoundMedicineImmunology +12