A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog

Justin K. Ichida, Joel Blanchard, Kelvin Lam, +12

Cell stem cell

Signal TransductionSignaling PathwayMedicineFibroblast Growth FactorInducing Nanog +5

Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming

Jie Deng, Robert Shoemaker, Bin Xie, +14

Nature Biotechnology

ChromatinDna SequencingEpigenetic ChangeGeneticsDna Methylation +7

Developmental reprogramming after chromosome transfer into mitotic mouse zygotes

Dieter Egli, Jacqueline Rosains, Garrett Birkhoff, +1

Nature

Chromosome TransferDevelopmental BiologyCell DivisionGeneticsMeiosis +7

Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants

Daniel Paull, Valentina Emmanuele, Keren A. Weiss, +11

Nature

ChromatinGenome InstabilityDnaMitochondrial FunctionNuclear Genome Transfer +8

Human oocytes reprogram somatic cells to a pluripotent state

Scott Noggle, Ho-Lim Fung, Athurva Gore, +13

Nature

OocyteInduced Pluripotent Stem CellStem Cell ResearchPluripotent StateMedicine +1

Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells

Mitsutoshi Yamada, Bjarki Jóhannesson, Ido Sagi, +13

Nature

Regenerative MedicineType 1Adult Somatic NucleiInduced Pluripotent Stem CellDevelopmental Biology +9

Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes

Mitsutoshi Yamada, Valentina Emmanuele, Maria J. Sanchez‐Quintero, +9

Cell stem cell

BiologyGenome InstabilityMitochondrial FunctionNatural SciencesGenetics +8

Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome

Lisa C. Burnett, Charles A. LeDuc, Carlos R. Sulsona, +21

Journal of Clinical Investigation

β-Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome

Linshan Shang, Haiqing Hua, Kylie S. Foo, +10

Diabetes

Adult Stem CellEr StressStem Cell BiologyInsulin SignalingStress +20

Long-term Safety and Efficacy of Human-Induced Pluripotent Stem Cell (iPS) Grafts in a Preclinical Model of Retinitis Pigmentosa

Yao Li, Yi‐Ting Tsai, Chun‐Wei Hsu, +6

Molecular Medicine