Mechanism of β ₂ AR regulation by an intracellular positive allosteric modulator

Xiangyu Liu, Ali Masoudi, Alem W. Kahsai, +11

Science

Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR

Xinyu Xu, Jonas Kaindl, Mary J. Clark, +6

Cell Research

Molecular PhysiologyFunctional SelectivityPhysiologyPathway DeterminesReceptor (Biochemistry) +4

An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor

Xiangyu Liu, Jonas Kaindl, Magdalena Korczynska, +13

Nature Chemical Biology

Molecular PharmacologySignal TransductionMolecular PhysiologyBiochemistryG Protein-coupled Receptor +9

Structural basis of α1A-adrenergic receptor activation and recognition by an extracellular nanobody

Yosuke Toyoda, Angqi Zhu, Fang Kong, +8

Nature Communications

A method for structure determination of GPCRs in various states

Qiong Guo, Binbin He, Yixuan Zhong, +9

Nature Chemical Biology

Materials ScienceVarious StatesEngineeringBiophysicsStructure Determination +6

Structural insights into human organic cation transporter 1 transport and inhibition

Shuhao Zhang, Angqi Zhu, Fang Kong, +9

Cell Discovery

Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor

Hossein Batebi, Guillermo Pérez‐Hernández, Sabrina N. Rahman, +15

Nature Structural & Molecular Biology

Molecular PharmacologySignal TransductionMolecular PhysiologyBiochemistryG Protein-coupled Receptor +8

Constrained catecholamines gain β2AR selectivity through allosteric effects on pocket dynamics

Xinyu Xu, Jeremy Shonberg, Jonas Kaindl, +12

Nature Communications

Structures of human prostaglandin F2α receptor reveal the mechanism of ligand and G protein selectivity

Xiuqing Lv, Kaixuan Gao, Jia Nie, +10

Nature Communications

Co-stabilization effects of gluten/carrageenan to the over-heated myofibrillar protein: Inhibit the undesirable gel weakening and protein over-aggregations

Xiangwei Zhu, Xiangyu Liu, Zhihan Ouyang, +9

International Journal of Biological Macromolecules