Detection of Epidermal Growth Factor Receptor Mutations in Serum as a Predictor of the Response to Gefitinib in Patients with Non–Small-Cell Lung Cancer

Hideharu Kimura, Kazuo Kasahara, Makoto Kawaishi, +4

Clinical Cancer Research

Non–small-cell Lung CancerSerum DnaMolecular Diagnostic TechniquesOncologySomatic Mutation +12

Insufficient autophagy in idiopathic pulmonary fibrosis

Jun Araya, Jun Kojima, Naoki Takasaka, +16

American Journal of Physiology-Lung Cellular and Molecular Physiology

MitophagyInflammatory Lung DiseaseAdvanced Lung DiseaseLung InflammationImmunology +15

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

Shunsuke Minagawa, Jun Araya, Takanori Numata, +9

American Journal of Physiology-Lung Cellular and Molecular Physiology

Acute Lung InjuryTgf-β-induced SenescenceInflammatory Lung DiseaseLung InflammationImmunology +17

PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis

Saburo Ito, Jun Araya, Yusuke Kurita, +18

Autophagy

Copd PathogenesisMitophagyGeneticsApoptosisCell Death +16

The Clinical Relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 Network in Chemoresistant Non-small-cell Lung Cancer

Yu Fujita, Shigehiro Yagishita, Keitaro Hagiwara, +11

Molecular Therapy

Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

Satoko Fujii, Hiromichi Hara, Jun Araya, +14

OncoImmunology

MitophagyUbiquitinated ProteinsLung InflammationImmunologyOxidative Stress +15

Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence

Hiromichi Hara, Jun Araya, Saburo Ito, +14

American Journal of Physiology-Lung Cellular and Molecular Physiology

Cell DeathMitochondrial BiologyOxidative StressDynamic OrganellesTobacco Control +16

Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence

Naoki Takasaka, Jun Araya, Hiromichi Hara, +21

The Journal of Immunology

MitophagyInflammatory Lung DiseaseLung InflammationAutophagy ActivationImmunology +18

Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis

Kenji Kobayashi, Jun Araya, Shunsuke Minagawa, +25

The Journal of Immunology

Pathogens in COPD exacerbations identified by comprehensive real-time PCR plus older methods

Kenichiro Shimizu, Yutaka Yoshii, Miyuki Morozumi, +20

International Journal of COPD