Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides

Nuria Izquierdo‐Useros, Maier Lorizate, María C. Puertas, +11

PLoS Biology

Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

Malika Aïd, Kathleen Busman‐Sahay, Samuel J. Vidal, +24

Cell

ThrombosisVascular DiseaseViral PersistenceViral PathogenesisVirology +2

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

Timothy N. Hoang, María Pino, Arun K. Boddapati, +42

Cell

InflammationCytokineBaricitinib TreatmentLung InflammationInnate Immune System +6

CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

Justin Harper, Shari N. Gordon, Chi Ngai Chan, +27

Nature Medicine

Human RetrovirusImmunologyAntiviral TherapyAntiviral ResponseAntiviral Drug +5

HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells

María Pino, Itziar Erkizia, Susana Benet, +12

Retrovirology

A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates

María Pino, Talha Abid, Susan Pereira Ribeiro, +44

Science Immunology

VaccinationMucosal VaccinationRbd ImmunogenVaccine DevelopmentVaccine Target +9

Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry

Daniel Perez‐Zsolt, Itziar Erkizia, María Pino, +10

Nature Microbiology

MedicineViral PathogenesisImmunologyAntiviral TherapyVirology +3

Predominance of Th2 cytokines, CXC chemokines and innate immunity mediators at the mucosal level during severe respiratory syncytial virus infection in children.

Jesús F. Bermejo-Martín, M. Carmen Garcia-Arevalo, Raúl Ortíz de Lejarazu, +8

PubMed

SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

Daniel Perez‐Zsolt, Jordana Muñoz‐Basagoiti, Jordi Rodon, +27

Cellular and Molecular Immunology

ImmunologyAntiviral ResponseDendritic Cell BiologyMedicineDendritic Cells

Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1

Daniel Perez‐Zsolt, Jon Cantero-Pérez, Itziar Erkizia, +13

Frontiers in Immunology