Modulation of <i>Escherichia coli</i> serine acetyltransferase catalytic activity in the cysteine synthase complex

Roberto Benoni, Omar De Bei, Gianluca Paredi, +5

FEBS Letters

Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine <i>O</i>-Acetyltransferase Inhibitor

Joana Magalhães, Nina Franko, Samanta Raboni, +8

ACS Medicinal Chemistry Letters

Investigational Studies on a Hit Compound Cyclopropane–Carboxylic Acid Derivative Targeting <i>O</i>-Acetylserine Sulfhydrylase as a Colistin Adjuvant

Giannamaria Annunziato, Costanza Spadini, Nina Franko, +13

ACS Infectious Diseases

Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of<i>O</i>-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR

Giannamaria Annunziato, Marco Pieroni, Roberto Benoni, +9

Journal of Enzyme Inhibition and Medicinal Chemistry

New ToolsSaturation Transfer DifferenceMolecular SciencesBiosynthesisCysteine Biosynthesis +13

Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design

Joana Magalhães, Nina Franko, Giannamaria Annunziato, +9

Journal of Enzyme Inhibition and Medicinal Chemistry

Cysteine BiosynthesisAntimicrobial ChemotherapyMedicinal ChemistryScaffold HoppingNovel Fragments +15

Inhibition of<i>O</i>-acetylserine sulfhydrylase by fluoroalanine derivatives

Nina Franko, Konstantinos Grammatoglou, Barbara Campanini, +3

Journal of Enzyme Inhibition and Medicinal Chemistry

Bioorganic ChemistryEnzyme InactivationBacterial PathogensDrug ResistanceStructure-function Enzyme Kinetics +14

Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets

Joana Magalhães, Giannamaria Annunziato, Nina Franko, +4

Journal of Chemical Information and Modeling

Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms

Joana Magalhães, Nina Franko, Giannamaria Annunziato, +9

Journal of Enzyme Inhibition and Medicinal Chemistry

Cysteine BiosynthesisOrganic ChemistryNew SeriesHeterocycle ChemistryChemical Biology +16

Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action

Brenda Rosa, Marialaura Marchetti, Gianluca Paredi, +10

International Journal of Molecular Sciences

Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria

Giannamaria Annunziato, Costanza Spadini, Marialaura Marchetti, +9

Pharmaceuticals