Genetic insights into biological mechanisms governing human ovarian ageing

Katherine S. Ruth, Felix R. Day, Jazib Hussain, +236

Nature

InfertilityDevelopmental BiologyLongevityGenetic InsightsMenopause +4

Penetrance of pathogenic genetic variants associated with premature ovarian insufficiency

Saleh Shekari, Stasa Stankovic, Eugene J. Gardner, +16

Nature Medicine

Disease SusceptibilityFertilityOvarian AgingFemale InfertilityPremature Ovarian Insufficiency +11

GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health

Yajie Zhao, Stasa Stankovic, Mine Koprulu, +10

Nature Communications

Damaging missense variants in IGF1R implicate a role for IGF-1 resistance in the etiology of type 2 diabetes

Eugene J. Gardner, Katherine A. Kentistou, Stasa Stankovic, +9

Cell Genomics

Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity

Lena R Kaisinger, Katherine A. Kentistou, Stasa Stankovic, +15

Cell Genomics

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Katherine A. Kentistou, Lena R Kaisinger, Stasa Stankovic, +106

Nature Genetics

GeneticsReproductive HealthGenetic EpidemiologyReproductive BiologyReproductive Endocrinology +27

Genetic links between ovarian ageing, cancer risk and de novo mutation rates

Stasa Stankovic, Saleh Shekari, Qin Qin Huang, +30

Nature

Genetic insights into the biological mechanisms governing human ovarian ageing

Katherine S. Ruth, Felix R. Day, Jazib Hussain, +226

Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint

Guillaume Combes, Helena Maria Barysz, Chantal Garand, +12

Current Biology

Damaging missense variants in <i>IGF1R</i> implicate a role for IGF-1 resistance in the aetiology of type 2 diabetes

Eugene J. Gardner, Katherine A. Kentistou, Stasa Stankovic, +9