Discovery of MRSA active antibiotics using primary sequence from the human microbiome

John Chu, Xavier Vila‐Farrés, Daigo Inoyama, +13

Nature Chemical Biology

Antimicrobial SusceptibilityHealth SciencesAntibioticsKlebsiella PneumoniaePrimary Sequence +9

Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist

Louis Cohen, Hahk‐Soo Kang, John Chu, +6

Proceedings of the National Academy of Sciences

Chemical-biogeographic survey of secondary metabolism in soil

Zachary Charlop–Powers, Jeremy G. Owen, Boojala Vijay B. Reddy, +2

Proceedings of the National Academy of Sciences

Global biogeographic sampling of bacterial secondary metabolism

Zachary Charlop–Powers, Jeremy G. Owen, Boojala Vijay B. Reddy, +7

eLife

BiologyMicrobial DiversityMicrobial SystematicsEngineeringMolecular Ecology +13

Malleilactone, a Polyketide Synthase-Derived Virulence Factor Encoded by the Cryptic Secondary Metabolome of Burkholderia pseudomallei Group Pathogens

John Biggins, Melinda A. Ternei, Sean F. Brady

Journal of the American Chemical Society

BiosynthesisEngineeringVirulence FactorPathogenesisBacteriology +12

Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products

Jeremy G. Owen, Boojala Vijay B. Reddy, Melinda A. Ternei, +4

Proceedings of the National Academy of Sciences

Multiplex SequencingEngineeringBiomolecular ToolEdna SequencesGenetics +21

Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors

Jeremy G. Owen, Zachary Charlop–Powers, Alexandra G. Smith, +5

Proceedings of the National Academy of Sciences

Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity

Zachary Charlop–Powers, Clara C. Pregitzer, Christophe Lemetre, +9

Proceedings of the National Academy of Sciences

Cadasides, Calcium-Dependent Acidic Lipopeptides from the Soil Metagenome That Are Active against Multidrug-Resistant Bacteria

Changsheng Wu, Zhuo Shang, Christophe Lemetre, +2

Journal of the American Chemical Society

EngineeringBiomolecular ToolMolecular BiologySecondary MetaboliteAntibiotic Resistance +19

Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism

James Peek, Mirjana Lilić, Daniel Montiel, +14

Nature Communications