mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass

Steven D. Kunkel, Manish Suneja, Scott M. Ebert, +6

Cell Metabolism

Systems BiologyMuscle FunctionMuscle InjurySkeletal MusclePhysiology +5

Stress-induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy

Scott M. Ebert, Michael C. Dyle, Steven D. Kunkel, +6

Journal of Biological Chemistry

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

Steven D. Kunkel, Christopher Elmore, Kale S. Bongers, +5

PLoS ONE

NutritionBrown FatSkeletal Muscle MassFatty Liver DiseaseInsulin Signaling +18

Systems-based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy

Michael C. Dyle, Scott M. Ebert, Daniel P. Cook, +6

Journal of Biological Chemistry

Skeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4

Kale S. Bongers, Daniel K. Fox, Scott M. Ebert, +5

American Journal of Physiology-Endocrinology and Metabolism

Muscle FunctionMolecular RegulationMolecular BiologySkeletal Muscle AtrophyCellular Physiology +18

The Transcription Factor ATF4 Promotes Skeletal Myofiber Atrophy during Fasting

Scott M. Ebert, Alex Mas Monteys, Daniel K. Fox, +6

Molecular Endocrinology

p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization

Daniel K. Fox, Scott M. Ebert, Kale S. Bongers, +5

American Journal of Physiology-Endocrinology and Metabolism

Immobilization-induced Muscle AtrophyMuscle FunctionEngineeringCytoskeletonMechanotransduction +16

Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy

Scott M. Ebert, Michael C. Dyle, Steven A. Bullard, +8

Journal of Biological Chemistry

Muscle FunctionAgingSkeletal MuscleSarcopeniaPhysiology +4

Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ

Scott M. Ebert, Steven A. Bullard, Nathan Basisty, +10

Journal of Biological Chemistry

Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4

Steven A. Bullard, Seongjin Seo, Birgit Schilling, +6

Journal of Biological Chemistry

Protein FunctionMolecular PhysiologySignal TransductionMuscle FunctionMusculoskeletal Research +7