Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

Rachel J. Perry, Liang Peng, Natasha A. Barry, +7

Nature

Metabolic SyndromePhysiologyMicrobiotaMetabolic RegulationMetabolism +5

Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

Katherine Chung, Jaffarguriqbal Singh, Lauren Lawres, +26

Cell

ObesityMetabolic SyndromePancreatic CancerGastroenterologyPathology +2

Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway

Sophie L. Lewandowski, Rebecca Cardone, Hannah R. Foster, +16

Cell Metabolism

Metabolic SyndromeSignal TransductionBiochemistryNatural SciencesDiabetes +11

Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis

Jeffrey C. Davis, Tiago C. Alves, Aharon Helman, +6

Cell Reports

Metabolic RemodelingPancreas TransplantationInsulin SignalingMetabolic SyndromeGlucose Response +17

Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats

Rachel J. Perry, Aviva Rabin-Court, Joongyu D. Song, +4

Nature Communications

Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health

Abudukadier Abulizi, Rebecca Cardone, Romana Stark, +15

Cell Metabolism

Whole-body Metabolic HealthEnergy MetabolismBiochemistryMitochondrial FunctionMitochondrial Phosphoenolpyruvate Cycle +10

Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms

Giuseppe Ferrandino, Rachel R. Kaspari, Olga Spadaro, +7

Proceedings of the National Academy of Sciences

Extrahepatic MechanismsImmunologyFatty Liver DiseaseInsulin SignalingAdipose Tissue Lipolysis +18

Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents

Rachel J. Perry, Rebecca Cardone, Max C. Petersen, +7

American Journal of Physiology-Endocrinology and Metabolism

Insulin SignalingGastrointestinal Peptide HormoneObesityMetabolic SyndromeMolecular Pharmacology +19

Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos

Sean R. Jesinkey, Anila K. Madiraju, Tiago C. Alves, +16

Cell Reports

Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis

Balkrishna Chaube, Kathryn M. Citrin, Mahnaz Sahraei, +9

Nature Communications